McIntosh M1, Genetic Engineering of Agrobacterium Increases Curdlan Production through Increased Expression of the crdASC Genes, Microorganisms, 2023, 10.3390/microorganisms12010055


Kretz J, Israel V, McIntosh M1, Design–Build–Test of Synthetic Promoters for Inducible Gene Regulation in Alphaproteobacteria, ACS Synthetic Biology, 2023,

Scheuer R,  Dietz T, Kretz J, Hadjeras L, McIntosh M,  Evguenieva-Hackenberg E, Incoherent dual regulation by a SAM-II riboswitch controlling translation at a distance, RNA Biology, Volume 19 –  Issue 1, 2022, 

Bettenworth V, van Vliet S, Turkowyd B, Bamberger A, Wendt H, McIntosh M, Steinchen W, Endesfelder U, Becker A, Frequency modulation of a bacterial quorum sensing response, Nature Communications volume 13, Article number: 2772, 2022,


McIntosh M1, Köchling T, Latz A, Kretz J, Heinen S, Konzer A, Klug G, A major checkpoint for protein expression in Rhodobacter sphaeroides during heat stress response occurs at the level of translation,  Environ Microbiol. 2021 Oct 19. doi: 10.1111/1462-2920.15818


Gruetzner J, Remes B, Eisenhardt K, Scheller D, Kretz J, Madhugiri R, McIntosh M, Klug G, sRNA-mediated RNA processing regulates bacterial cell division. Nucleic Acids Research, 2021, 49(21):7035–7052


McIntosh M, Kretz J, Abbau von Braunalgen. Biospektrum (Heidelb), 2020, 26(6):646-651. doi: 10.1007/s12268-020-1461-8


McIntosh M, Kretz J, Stickstofffixierung: Freundschaft oder Knechtschaft? Biospektrum (Heidelb), 2020, 26(6):646-651. doi: 10.1007/s12268-020-1461-8


McIntosh M1, Eisenhardt K, Remes B, Konzer A, Klug G, Adaptation of the Alphaproteobacterium Rhodobacter sphaeroides to stationary phase. Environmental Microbiology, 2019, 21: 4425-4445


Ludueña LM, Anzuay MS, Angelini JG, McIntosh M, Becker A, Rupp O, Goesmann A, Blom J, Fabra A, Taurian T, Genome sequence of the endophytic strain Enterobacter sp. J49, a potential biofertilizer for peanut and maize. Genomics, 2019, 111: 913-920


McIntosh M1, Serrania J, Lacanna E, A novel LuxR-type solo of Sinorhizobium meliloti, NurR, is regulated by the chromosome replication coordinator, DnaA, and activates quorum sensing. Molecular Microbiology, 2019, 112: 678-698


Bathke J, Konzer A, Remes B, McIntosh M1, Klug G, Comparative analyses of the variation of the transcriptome and proteome of Rhodobacter sphaeroides throughout growth. BMC Genomics, 2019, 20: 358. doi: 10.1186/s12864-019-5749-3


Calatrava-Morales N, McIntosh M, Soto MJ1, Regulation Mediated by N-Acyl Homoserine Lactone Quorum Sensing Signals in the Rhizobium-Legume Symbiosis. Genes (Basel), 2018, 9:263. doi: 10.3390/genes9050263


Bettenworth V, McIntosh M, Becker A, Eckhardt B1, Front-propagation in bacterial inter-colony communication. Chaos, 2018, 28: 106316. Doi: 10.1063/1.5040068


Ludueña LM, Anzuay MS, Angelini JG, McIntosh M, Becker A, Rupp O, Goesmann A, Blom J, Fabra A, Taurian T, Strain Serratia sp. S119: A potential biofertilizer for peanut and maize and a model bacterium to study phosphate solubilization mechanisms. Applied Soil Ecology 126, 2018, doi: 10.1016/j.apsoil.2017.12.024


Baumgardt K, Melior H, Madhugiri R, Thalmann S, Schikora A, McIntosh M, Becker A, Evguenieva-Hackenberg E1, RNase E and RNase J are needed for S-adenosylmethionine homeostasis in Sinorhizobium meliloti. Microbiology (Reading), 2017, 163: 570-583


Ludueña LM, Anzuay MS, Magallanes-Noguera C, Tonelli ML, Ibañez FJ, Angelini JG, Fabra A, McIntosh M, Taurian T1, Effects of P limitation and molecules from peanut root exudates on pqqE gene expression and pqq promoter activity in the phosphate-solubilizing strain Serratia sp. S119. Res Microbiol, 2017, 168: 710-721


Charoenpanich P, Soto MJ, Becker A, McIntosh M1, Quorum sensing restrains growth and is rapidly inactivated during domestication of Sinorhizobium meliloti. Environmental Microbiology Reports, 2015, 7: 373-382


Schlüter JP, Czuppon P, Schauer O, Pfaffelhuber P, McIntosh M1, Becker A1, Classification of phenotypic subpopulations in isogenic bacterial cultures by triple promoter probing at single cell level. Journal of Biotechnology, 2015, 198: 3-14


Vinardell JM, Acosta-Jurado S, Zehner S, Göttfert M, Becker A, Baena I, Blom J, Crespo-Rivas JC, Goesmann A, Jaenicke S, Krol E, McIntosh M, Margaret I, Pérez-Montaño F, Schneiker-Bekel S, Serranía J, Szczepanowski R, Buendía AM, Lloret J, Bonilla I, Pühler A, Ruiz-Sainz JE, Weidner S, The Sinorhizobium fredii HH103 Genome: A comparative analysis with S. fredii strains differing in their symbiotic behavior with soybean. Mol Plant Microbe Interact, 2015 28:811-24


Baumgardt K, Charoenpanich P, McIntosh M, Schikora A, Stein E, Thalmann S, Kogel KH, Klug G, Becker A, Evguenieva-Hackenberg E1, RNase E affects the expression of the acyl-homoserine lactone synthase gene sinI in Sinorhizobium meliloti. Journal of Bacteriology, 2014, 196: 1435-47


McIntosh M, Czuppon P, Best K, Becker A, Pfaffelhuber P1, Modeling Quorum Sensing in Sinorhizobium meliloti. International Journal of Biomathematics and Biostatistics, 2013, 2:59-74


Carius L, Carius A, McIntosh M, Grammel H1, Quorum sensing influences growth and photosynthetic membrane production in high-cell-density cultivations of Rhodospirillum rubrum. BMC Microbiology, 2013, doi: 10.1186/1471-2180-13-189


Charoenpanich P, Meyer S, Becker A1, McIntosh M, Temporal Expression Program of Quorum Sensing-Based Transcription Regulation in Sinorhizobium meliloti. Journal of Bacteriology, 2013, 195: 3224-3236


McIntosh M, Meyer S, Becker A1, Novel Sinorhizobium meliloti quorum sensing positive and negative regulatory feedback mechanisms respond to phosphate availability. Molecular Microbiology, 2009, 74: 1238-1256


Wollschläger K, Gaus K, Körnig A, Eckel R, Wilking S-D, McIntosh M, Majer Z, Becker A, Ros R, Anselmetti D, Sewald N, Single-Molecule Experiments to Elucidate the Minimal Requirement for DNA Recognition by Transcription Factor Epitopes. Small 2009, 5(4):484-95


McIntosh M, Krol E, Becker A1, Competitive and Cooperative Effects in Quorum-Sensing-Regulated Galactoglucan Biosynthesis in Sinorhizobium meliloti. Journal of Bacteriology, 2008, 190: 5308-5317


Bahlawane C, McIntosh M, Krol E, Becker A1, Sinorhizobium meliloti regulator MucR couples exopolysaccharide synthesis and motility. Mol Plant Microbe Interact, 2008, 21:1498-509


Anselmetti D, Bartels FW, Becker A, Decker B, Eckel R, McIntosh M, Mattay J, Plattner P, Ros R, Schäfer C, Sewald N1, Reverse engineering of an affinity-switchable molecular interaction characterized by atomic force microscopy single-molecule force spectroscopy. Langmuir, 2008, 24: 1365-70


Bartels FW, McIntosh M, Fuhrmann A, Metzendorf C, Plattner P, Sewald N, Anselmetti D, Ros R, Becker A1, Effector-stimulated single molecule protein-DNA interactions of a quorum-sensing system in Sinorhizobium meliloti. Biophysics Journal, 2007, 92: 4391-400


McIntosh M, Stone B, Stanisich V, Curdlan and other bacterial (1‎→3)-beta-D-glucans. Applied Microbiology and Biotechnology, 2005, 68(2): 163-73


Karnezis T, McIntosh M, Wardak AZ, Stanisich V, Stone B, The Biosynthesis of β-Glycans. Trends in Glycoscience and Glycotechnology, 2000, 12(66):211-227



Method for producing curdlan and usage thereof (application no. EP 23210906.6): Filing date: 20. of Nov. 2023, published on 23. of February 2023, applicant: Justus-Liebig-Universität Giessen, inventors: McIntosh M1, European Patent Office (EPO), 10.3390/microorganisms12010055 


Chromosomal integrating cassette allowing inducible gene expression for production of compounds via fermentation (application no WO2023021108): International filing date: 17. of August 2022, published on 23. of February 2023, applicant: Justus-Liebig-Universität Giessen, inventors:

Kretz J, Klug G, McIntosh M1, World Intellectual Property Organization,

(1 indicates corresponding author)


Related publications:

How bacteria can be “tamed” for sustainable plastics production, Research team at Giessen University develops new system for tailored control of gene expression, CHEMEUROPE, Aug. 17, 2023,


Marjorie Hecht, German researchers find heat stress in Rhodobacter sphaeroides bacteria causes dramatic changes in RNA without affecting protein levels, Current Science Daily, May 11, 2022,




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