Kretz J, Israel V, McIntosh M1, Design–Build–Test of Synthetic Promoters for Inducible Gene Regulation in Alphaproteobacteria, ACS Synthetic Biology, 2023, (gene regulation)

Patent application WO2023021108: Chromosomal integrating cassette allowing inducible gene expression for production of compounds via fermentation. International filing date: 17. of August 2022, published on 23. of February 2023, applicant: Justus-Liebig-Universität Giessen, inventors:

Kretz J, Klug G, McIntosh M1, World Intellectual Property Organization, (gene regulation)

Scheuer R,  Dietz T, Kretz J, Hadjeras L, McIntosh M,  Evguenieva-Hackenberg E, Incoherent dual regulation by a SAM-II riboswitch controlling translation at a distance, RNA Biology, Volume 19 –  Issue 1, 2022, (gene regulation)

Bettenworth V, van Vliet S, Turkowyd B, Bamberger A, Wendt H, McIntosh M, Steinchen W, Endesfelder U, Becker A, Frequency modulation of a bacterial quorum sensing response, Nature Communications volume 13, Article number: 2772, 2022, (gene regulation)

McIntosh M1, Köchling T, Latz A, Kretz J, Heinen S, Konzer A, Klug G, A major checkpoint for protein expression in Rhodobacter sphaeroides during heat stress response occurs at the level of translation,  Environ Microbiol. 2021 Oct 19. doi: 10.1111/1462-2920.15818 (gene regulation)

Gruetzner J, Remes B, Eisenhardt K, Scheller D, Kretz J, Madhugiri R, McIntosh M, Klug G, sRNA-mediated RNA processing regulates bacterial cell division. Nucleic Acids Research, 2021, 49(21):7035–7052 (gene regulation)

McIntosh M, Kretz J, Abbau von Braunalgen. Biospektrum (Heidelb), 2020, 26(6):646-651. doi: 10.1007/s12268-020-1461-8 (general)

McIntosh M, Kretz J, Stickstofffixierung: Freundschaft oder Knechtschaft? Biospektrum (Heidelb), 2020, 26(6):646-651. doi: 10.1007/s12268-020-1461-8 (general)

McIntosh M1, Eisenhardt K, Remes B, Konzer A, Klug G, Adaptation of the Alphaproteobacterium Rhodobacter sphaeroides to stationary phase. Environmental Microbiology, 2019, 21: 4425-4445 (gene regulation)

Ludueña LM, Anzuay MS, Angelini JG, McIntosh M, Becker A, Rupp O, Goesmann A, Blom J, Fabra A, Taurian T, Genome sequence of the endophytic strain Enterobacter sp. J49, a potential biofertilizer for peanut and maize. Genomics, 2019, 111: 913-920 (general)

McIntosh M1, Serrania J, Lacanna E, A novel LuxR-type solo of Sinorhizobium meliloti, NurR, is regulated by the chromosome replication coordinator, DnaA, and activates quorum sensing. Molecular Microbiology, 2019, 112: 678-698 (gene regulation and biopolymer production)

Bathke J, Konzer A, Remes B, McIntosh M1, Klug G, Comparative analyses of the variation of the transcriptome and proteome of Rhodobacter sphaeroides throughout growth. BMC Genomics, 2019, 20: 358. doi: 10.1186/s12864-019-5749-3 (gene regulation)

Calatrava-Morales N, McIntosh M, Soto MJ1, Regulation Mediated by N-Acyl Homoserine Lactone Quorum Sensing Signals in the Rhizobium-Legume Symbiosis. Genes (Basel), 2018, 9:263. doi: 10.3390/genes9050263 (gene regulation)

Bettenworth V, McIntosh M, Becker A, Eckhardt B1, Front-propagation in bacterial inter-colony communication. Chaos, 2018, 28: 106316. Doi: 10.1063/1.5040068 (general)

Ludueña LM, Anzuay MS, Angelini JG, McIntosh M, Becker A, Rupp O, Goesmann A, Blom J, Fabra A, Taurian T, Strain Serratia sp. S119: A potential biofertilizer for peanut and maize and a model bacterium to study phosphate solubilization mechanisms. Applied Soil Ecology 126, 2018, doi: 10.1016/j.apsoil.2017.12.024 (general)

Baumgardt K, Melior H, Madhugiri R, Thalmann S, Schikora A, McIntosh M, Becker A, Evguenieva-Hackenberg E1, RNase E and RNase J are needed for S-adenosylmethionine homeostasis in Sinorhizobium meliloti. Microbiology (Reading), 2017, 163: 570-583 (gene regulation)

Ludueña LM, Anzuay MS, Magallanes-Noguera C, Tonelli ML, Ibañez FJ, Angelini JG, Fabra A, McIntosh M, Taurian T1, Effects of P limitation and molecules from peanut root exudates on pqqE gene expression and pqq promoter activity in the phosphate-solubilizing strain Serratia sp. S119. Res Microbiol, 2017, 168: 710-721 (general)

Charoenpanich P, Soto MJ, Becker A, McIntosh M1, Quorum sensing restrains growth and is rapidly inactivated during domestication of Sinorhizobium meliloti. Environmental Microbiology Reports, 2015, 7: 373-382 (gene regulation and biopolymer production)

Schlüter JP, Czuppon P, Schauer O, Pfaffelhuber P, McIntosh M1, Becker A1, Classification of phenotypic subpopulations in isogenic bacterial cultures by triple promoter probing at single cell level. Journal of Biotechnology, 2015, 198: 3-14 (general)

Vinardell JM, Acosta-Jurado S, Zehner S, Göttfert M, Becker A, Baena I, Blom J, Crespo-Rivas JC, Goesmann A, Jaenicke S, Krol E, McIntosh M, Margaret I, Pérez-Montaño F, Schneiker-Bekel S, Serranía J, Szczepanowski R, Buendía AM, Lloret J, Bonilla I, Pühler A, Ruiz-Sainz JE, Weidner S, The Sinorhizobium fredii HH103 Genome: A comparative analysis with S. fredii strains differing in their symbiotic behavior with soybean. Mol Plant Microbe Interact, 2015 28:811-24 (general)

Baumgardt K, Charoenpanich P, McIntosh M, Schikora A, Stein E, Thalmann S, Kogel KH, Klug G, Becker A, Evguenieva-Hackenberg E1, RNase E affects the expression of the acyl-homoserine lactone synthase gene sinI in Sinorhizobium meliloti. Journal of Bacteriology, 2014, 196: 1435-47 (gene regulation)

McIntosh M, Czuppon P, Best K, Becker A, Pfaffelhuber P1, Modeling Quorum Sensing in Sinorhizobium meliloti. International Journal of Biomathematics and Biostatistics, 2013, 2:59-74 (gene regulation)

Carius L, Carius A, McIntosh M, Grammel H1, Quorum sensing influences growth and photosynthetic membrane production in high-cell-density cultivations of Rhodospirillum rubrum. BMC Microbiology, 2013, doi: 10.1186/1471-2180-13-189 (general)

Charoenpanich P, Meyer S, Becker A1, McIntosh M, Temporal Expression Program of Quorum Sensing-Based Transcription Regulation in Sinorhizobium meliloti. Journal of Bacteriology, 2013, 195: 3224-3236 (gene regulation)


McIntosh M, Meyer S, Becker A1, Novel Sinorhizobium meliloti quorum sensing positive and negative regulatory feedback mechanisms respond to phosphate availability. Molecular Microbiology, 2009, 74: 1238-1256 (gene regulation)

Wollschläger K, Gaus K, Körnig A, Eckel R, Wilking S-D, McIntosh M, Majer Z, Becker A, Ros R, Anselmetti D, Sewald N, Single-Molecule Experiments to Elucidate the Minimal Requirement for DNA Recognition by Transcription Factor Epitopes. Small 2009, 5(4):484-95 (general)

McIntosh M, Krol E, Becker A1, Competitive and Cooperative Effects in Quorum-Sensing-Regulated Galactoglucan Biosynthesis in Sinorhizobium meliloti. Journal of Bacteriology, 2008, 190: 5308-5317 (gene regulation and biopolymer production)

Bahlawane C, McIntosh M, Krol E, Becker A1, Sinorhizobium meliloti regulator MucR couples exopolysaccharide synthesis and motility. Mol Plant Microbe Interact, 2008, 21:1498-509 (gene regulation)

Anselmetti D, Bartels FW, Becker A, Decker B, Eckel R, McIntosh M, Mattay J, Plattner P, Ros R, Schäfer C, Sewald N1, Reverse engineering of an affinity-switchable molecular interaction characterized by atomic force microscopy single-molecule force spectroscopy. Langmuir, 2008, 24: 1365-70 (general)

Bartels FW, McIntosh M, Fuhrmann A, Metzendorf C, Plattner P, Sewald N, Anselmetti D, Ros R, Becker A1, Effector-stimulated single molecule protein-DNA interactions of a quorum-sensing system in Sinorhizobium meliloti. Biophysics Journal, 2007, 92: 4391-400 (gene regulation)

McIntosh M, Stone B, Stanisich V, Curdlan and other bacterial (1‎→3)-beta-D-glucans. Applied Microbiology and Biotechnology, 2005, 68(2): 163-73 (biopolymer production)

Karnezis T, McIntosh M, Wardak AZ, Stanisich V, Stone B, The Biosynthesis of β-Glycans. Trends in Glycoscience and Glycotechnology, 2000, 12(66):211-227 (biopolymer production)

(1 indicates corresponding author)

Related publications:

Marjorie Hecht, German researchers find heat stress in Rhodobacter sphaeroides bacteria causes dramatic changes in RNA without affecting protein levels, Current Science Daily, May 11, 2022,



Just recently, an invention of mine was claimed by JLU Giessen and is being prepared for filing with the patent office. The invention of the patent is a genetically engineered construct that modifies the chromosome to allow inducible gene expression. The problem addressed by this patent is the situation where an abundance of inducible gene expression systems exist for model bacteria such as Escherichia coli and Bacillus subtilis, but these do not work well or at all for the vast majority of less studied microbes. Many non-model bacteria have great potential for bioproduction, but could still benefit greatly from genetic modification. My invention will provide a way to genetically manipulate gene expression in almost any bacterium of industrial interest.

Update August 2023: The patent has been accepted by the European Patent Office (EPO) and is currently under review by the World Intellectual Property Organization.


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