Gene regulation:


Gruetzner J, Remes B, Eisenhardt K, Scheller D, Kretz J, Madhugiri R, McIntosh M, Klug G, sRNA-mediated RNA processing regulates bacterial cell division. Nucleic Acids Research, accepted for publication May 2021


McIntosh M1, Eisenhardt K, Remes B, Konzer A, Klug G, Adaptation of the Alphaproteobacterium Rhodobacter sphaeroides to stationary phase. Environmental Microbiology, 2019, 21: 4425-4445


Bathke J, Konzer A, Remes B, McIntosh M1, Klug G, Comparative analyses of the variation of the transcriptome and proteome of Rhodobacter sphaeroides throughout growth. BMC Genomics, 2019, 20: 358. doi: 10.1186/s12864-019-5749-3.


Calatrava-Morales N, McIntosh M, Soto MJ1, Regulation Mediated by N-Acyl Homoserine Lactone Quorum Sensing Signals in the Rhizobium-Legume Symbiosis. Genes (Basel), 2018, 9:263. doi: 10.3390/genes9050263


Baumgardt K, Melior H, Madhugiri R, Thalmann S, Schikora A, McIntosh M, Becker A, Evguenieva-Hackenberg E1, RNase E and RNase J are needed for S-adenosylmethionine homeostasis in Sinorhizobium meliloti. Microbiology (Reading), 2017, 163: 570-583


Baumgardt K, Charoenpanich P, McIntosh M, Schikora A, Stein E, Thalmann S, Kogel KH, Klug G, Becker A, Evguenieva-Hackenberg E1, RNase E affects the expression of the acyl-homoserine lactone synthase gene sinI in Sinorhizobium meliloti. Journal of Bacteriology, 2014, 196: 1435-47


McIntosh M, Czuppon P, Best K, Becker A, Pfaffelhuber P1, Modeling Quorum Sensing in Sinorhizobium meliloti. International Journal of Biomathematics and Biostatistics, 2013, 2:59-74


Charoenpanich P, Meyer S, Becker A1, McIntosh M, Temporal Expression Program of Quorum Sensing-Based Transcription Regulation in Sinorhizobium meliloti. Journal of Bacteriology, 2013, 195: 3224-3236


McIntosh M, Meyer S, Becker A1, Novel Sinorhizobium meliloti quorum sensing positive and negative regulatory feedback mechanisms respond to phosphate availability. Molecular Microbiology, 2009, 74: 1238-1256


Bahlawane C, McIntosh M, Krol E, Becker A1, Sinorhizobium meliloti regulator MucR couples exopolysaccharide synthesis and motility. Mol Plant Microbe Interact, 2008, 21:1498-509


Bartels FW, McIntosh M, Fuhrmann A, Metzendorf C, Plattner P, Sewald N, Anselmetti D, Ros R, Becker A1, Effector-stimulated single molecule protein-DNA interactions of a quorum-sensing system in Sinorhizobium meliloti. Biophysics Journal, 2007, 92: 4391-400



Biopolymer production:


McIntosh M, Stone B, Stanisich V, Curdlan and other bacterial (1‎→3)-beta-D-glucans. Applied Microbiology and Biotechnology, 2005, 68(2): 163-73


Karnezis T, McIntosh M, Wardak AZ, Stanisich V, Stone B, The Biosynthesis of β-Glycans. Trends in Glycoscience and Glycotechnology, 2000, 12(66):211-227



Gene regulation and biopolymer production:


McIntosh M1, Serrania J, Lacanna E, A novel LuxR-type solo of Sinorhizobium meliloti, NurR, is regulated by the chromosome replication coordinator, DnaA, and activates quorum sensing. Molecular Microbiology, 2019, 112: 678-698


Charoenpanich P, Soto MJ, Becker A, McIntosh M1, Quorum sensing restrains growth and is rapidly inactivated during domestication of Sinorhizobium meliloti. Environmental Microbiology Reports, 2015, 7: 373-382


McIntosh M, Krol E, Becker A1, Competitive and Cooperative Effects in Quorum-Sensing-Regulated Galactoglucan Biosynthesis in Sinorhizobium meliloti. Journal of Bacteriology, 2008, 190: 5308-5317





Matthew McIntosh, Jonas Kretz, Stickstofffixierung: Freundschaft oder Knechtschaft? Biospektrum (Heidelb), 2020;26(6):646-651. doi: 10.1007/s12268-020-1461-8.


Matthew McIntosh, Jonas Kretz, Abbau von Braunalgen. Biospektrum (Heidelb), 2020;26(6):646-651. doi: 10.1007/s12268-020-1461-8.


Ludueña LM, Anzuay MS, Angelini JG, McIntosh M, Becker A, Rupp O, Goesmann A, Blom J, Fabra A, Taurian T, Genome sequence of the endophytic strain Enterobacter sp. J49, a potential biofertilizer for peanut and maize. Genomics, 2019, 111: 913-920


Bettenworth V, McIntosh M, Becker A, Eckhardt B1, Front-propagation in bacterial inter-colony communication. Chaos, 2018, 28: 106316. Doi: 10.1063/1.5040068


Ludueña LM, Anzuay MS, Angelini JG, McIntosh M, Becker A, Rupp O, Goesmann A, Blom J, Fabra A, Taurian T, Strain Serratia sp. S119: A potential biofertilizer for peanut and maize and a model bacterium to study phosphate solubilization mechanisms. Applied Soil Ecology 126, 2018, doi: 10.1016/j.apsoil.2017.12.024


Ludueña LM, Anzuay MS, Magallanes-Noguera C, Tonelli ML, Ibañez FJ, Angelini JG, Fabra A, McIntosh M, Taurian T1, Effects of P limitation and molecules from peanut root exudates on pqqE gene expression and pqq promoter activity in the phosphate-solubilizing strain Serratia sp. S119. Res Microbiol, 2017, 168: 710-721


Schlüter JP, Czuppon P, Schauer O, Pfaffelhuber P, McIntosh M1, Becker A1, Classification of phenotypic subpopulations in isogenic bacterial cultures by triple promoter probing at single cell level. Journal of Biotechnology, 2015, 198: 3-14


Vinardell JM, Acosta-Jurado S, Zehner S, Göttfert M, Becker A, Baena I, Blom J, Crespo-Rivas JC, Goesmann A, Jaenicke S, Krol E, McIntosh M, Margaret I, Pérez-Montaño F, Schneiker-Bekel S, Serranía J, Szczepanowski R, Buendía AM, Lloret J, Bonilla I, Pühler A, Ruiz-Sainz JE, Weidner S, The Sinorhizobium fredii HH103 Genome: A comparative analysis with S. fredii strains differing in their symbiotic behavior with soybean. Mol Plant Microbe Interact, 2015 28:811-24


Carius L, Carius A, McIntosh M, Grammel H1, Quorum sensing influences growth and photosynthetic membrane production in high-cell-density cultivations of Rhodospirillum rubrum. BMC Microbiology, 2013, doi: 10.1186/1471-2180-13-189


Wollschläger K, Gaus K, Körnig A, Eckel R, Wilking S-D, McIntosh M, Majer Z, Becker A, Ros R, Anselmetti D, Sewald N, Single-Molecule Experiments to Elucidate the Minimal Requirement for DNA Recognition by Transcription Factor Epitopes. Small 2009, 5(4):484-95


Anselmetti D, Bartels FW, Becker A, Decker B, Eckel R, McIntosh M, Mattay J, Plattner P, Ros R, Schäfer C, Sewald N1, Reverse engineering of an affinity-switchable molecular interaction characterized by atomic force microscopy single-molecule force spectroscopy. Langmuir, 2008, 24: 1365-70


(1 indicates corresponding author)




Just recently an invention from me was claimed by the JLU Giessen and is being prepared for submission to the patent office. The invention of the patent is a genetically engineered construct which modifies the chromosome to allow inducible gene expression. The problem that this patent addresses is the situation where a wealth of inducible gene expression systems exists for model bacteria such as Escherichia coli and Bacillus subtilis, but these are nonfunctional or function poorly in the vast majority of lesser studied microbes. Many non-model bacteria have been identified as having great potential for bioproduction, but could nonetheless greatly benefit from genetic modification. My invention will provide a way to genetically manipulate gene expression in any bacterium of industrial interest. 


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